Internal dosimetry is of critical importance to obtain an accurate absorbed doseresponse relationship during preclinical molecular imaging and targeted radionuclide therapy trt. These departures from traditional occupational internal dose assessment have created a need for the development of new approaches as well as new software to accomplish the goal. Conventionally, absorbed dose calculations have been performed using organ level dosimetry based on the medical internal radiation dose mird schema. This gives a rough estimate of the level of severity of the risk involved from any radiologic examination. Mird is listed in the worlds largest and most authoritative dictionary database of. In this study, radiation absorbed doses and effective doses were calculated based on the radar method by entering the timeintegrated activity coefficient formerly known as residence time of each source organ into olindaexm 1. Monte carlo calculation of imaging doses from diagnostic multidetector ct and kilovoltage cone beam ct as part of prostate cancer treatment plans. Epa bases its radiation protection activities on scientific assessment of health risks posed by radioactive substances. The input parameters required by the olinda software for the estimation of the absorbed dose are the type of radionuclide, a phantom or phantoms, and the number.
Mirdose outdated by olindaexm organ level internal dose assessmentexponential modeling olindaexm online calculators. Ct dose not that small 45 ct scans are used for imageguided radiation therapy igrt a p ding, j w gu, x g xu, trofimov av. Internal dose concepts are employed when radioactive material enters the body through any pathway, either in a workplace situation, in the nuclear medicine clinic where the intakes are quite intentional, from eating or drinking contaminated food and water, and other such situations. For each organ, the equivalent dose, which is the absorbed radiation dose weighted for the degree of the biological effect of different types of radiation, was calculated. Early internal and external dose magnitude estimation. Technology olindaexm radiation dose assessment software. Claims where it is apparent that a large dose was delivered to the relevant organ can be expedited by performing a partial dose assessment. Vu0338olindaexm radiation dose assessment software. The authors objective was to compare internal dose estimates obtained using the organ level dose assessment with exponential modeling olindaexm software, the voxel s value technique, and monte carlo simulation.
Preclinical safety assessment of the 5ht 2a receptor. In addition, a new section of code was added that allowed users to. There are many variables that come into play when doing external dose estimation. Olindaexm is a personal computer code for calculating organ doses and effective doses in nuclear medicine studies was developed in 2004. An update of virtualdose software used for assessing.
A new tool, named oedipe a french acronym that stands for tool for personalized internal dose assessment was developed to carry out personalized internal dosimetry calculations for nuclear medicine for both therapeutic and diagnostic procedures and for radiation safety in the case of internal contamination. The code olindaexm, which is an acronym standing for organ level internal dose assessmentexponential modeling, was designed as an update to mirdose. About internal dose assessment in nuclear medicine. Radiation risk may refer to all excess cancers caused by radiation exposure incidence. Radiation exposure of the body and critical organs was calculated from the 18fmk3328 residence times using olinda organ level internal dose assessment software. Radar internalnuclear medicine radar the radiation dose. Comparison of internal dose estimates obtained using organ. The olindaexm personal computer code performs dose calculations and. Olindaexm organ level internal dose assessmentexponential modeling. However, the accuracy for individualized organ dose assessment is still. Monte carlo dose estimates were used as the reference standard to assess the impact of patientspeci. This code was completely rewritten and renamed olinda organ level internal dose assessment stabin et al. The effective dose ed per organ will be calculated using organ level internal dose assessment olinda software.
Radar medical procedure radiation dose calculator and consent language generator. Radiation dosimetry calculation internal dosimetry estimates were calculated using the organ level internal dose assessment olinda software v. The olindaexm personal computer code for calculating organ doses and effective. Epas sciencebased tools help radiation protection professionals calculate radiation dose and risk risk the probability of injury, disease or death from exposure to a hazard.
Committee on medical internal radiation dose mird snmmi. Eanm dose calculator for clinical radiopharmaceutical administration. Shen s, denardo gl, macey dj, odonnell rt, yuan a, denardo da et al. The radioactivity dose 370 to 740 mbq, 10 to 20 mci is chosen based on patient body dimensions and the characteristics of the. Early internal and external dose estimation initial version.
The 5ht 2a receptor agonist actions of 11 ccimbi36 in vivo pharmacological effects in mice elicited by increasing doses of cimbi36 were assessed with the headtwitch response htr. Olindaexm organ level internal dose assessmentexponential. Olindaexm organ level internal dose assessmentexponential modeling 1 jan 2019 27 jun 2019 olindaexm is a personal computer code for calculating organ doses and effective doses in nuclear medicine studies was developed in 2004. For some radioisotopes, such as many of those in the actinide series 241am, the plutonium isotopes, etc. The personal computer code olindaexm, which is an acronym standing for organ level internal dose assessment exponential modeling, was designed as an update to mirdose. Preclinical evaluation of 18ffba20fmdv2 as a selective. Most of the main functions of mirdose were retained, but some new models were added. Olinda calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on usersupplied biokinetic. The olinda exm application is widely used in the radiopharmaceutical industry and research community for internal dose calculations of radiopharmaceuticals. Thresholded datasets were used to hand draw threedimensional regions of interest over all of the major organs showing visually appreciable uptake greater than that in the background tissue table 2. Tools for calculating radiation dose and risk us epa. Fyi, the predecessor of the olindaexm organ level internal dose assessmentexponential modeling version 1. The personal computer code olinda, which is an acronym standing for organ level internal dose assessmentexponential modeling, calculates radiation doses to different organs of the body from radiopharmaceuticals which are administered systemically mostly intravenously, but sometimes by oral or. Based on animal data, the organ level internal dose assessment software was used to estimate extrapolated human dosimetry for 11 ccimbi36.
Pmod pmod technologies zurich, switzerland, imaging software. Practical determination of organ s values for individual patients for therapy. The mird committee develops standard methods, models, assumptions, and mathematical schema for assessing internal radiation doses from administered radiopharmaceuticals. Therefore, the code was completely rewritten in the java sun microsystems programming language and was renamed olinda for organ level internal dose assessment. Looking for online definition of mird or what mird stands for. Click here to see some sample screens from the software.
Olindaexm, which stands for organ level internal dose assessmentexponential modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression. Organ level internal dose assessmentexponential modeling software from vanderbilt university. Olindaexm radiation dose assessment software application. Committee on medical internal radiation dose mird radiation dosimetry provides the fundamental quantities used for radiation protection, risk assessment, and treatment planning. Axumin fda prescribing information, side effects and uses. Radar software radar the radiation dose assessment. The organ level internal dose assessment code, olinda, with an exponential modeling exm function, is the update and replacement of the mirdose personal computer software. Based on animal data, the organ level internal dose assessment software was used to estimate extrapolated human dosimetry for 11ccimbi36.
Olindaexm, which stands for organ level internal dose assessment exponential modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on usersupplied biokinetic. The preferred dose estimate from an individual risk assessment is the annual absorbed organ dose. Some of these items are usually fairly straight forward, source activity and isotope, for instance. Dosimetry software such as medical internal radiation dose mirdose 75 or organ level internal dose assessment exponential modeling olindaexm, successor to mirdose, fda 510kapproved device 71 offer users a variety of phantoms that permit calculating radiation doses for individuals at various ages and sizes, and for women at different. Biodistribution and radiation dosimetry of ejnmmi research. After injection of 370 megabecquerel mbq of 18fjnj64326067, a series of wholebody positron emission tomography pet images will be obtained over a period of up to 6 hours and corrected for attenuation by computed tomography ct transmission scans using. Values were calculated from human biodistribution data using olindaexm organ level internal dose assessment exponential modeling software. Radiopharmadose, a javabased opensource software for. Organ dosimetry values were calculated by using organ level internal dose assessment software vanderbilt university, 2003 32. Pilot pharmacokinetic and dosimetric studies of 18f. As with the comprehensive dose assessment, the radiation dose from internal sources as a result of either inhalation or ingestion can use pbpk models. Olindaexm, which stands for organ level internal dose assessmentexponential modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and. Among the things to consider are time of exposure, distance from the source, source activity, potential shielding, and isotope. Dailymed axumin fluciclovine f18 injection, solution.
Just like for mirdose, users will enter results of kinetic models into the code, which uses them with models of the human body which have been established in the literature to. A study to investigate the whole body distribution and. The radiation absorbed effective dose resulting from the administration of the recommended activity of 370 mbq of axumin is 8 msv. The personal computer code olindaexm, which is an acronym standing for organ level internal dose assessmentexponential modeling, was designed as an update to mirdose. The new version has been enhanced and includes new human models and nuclides. Epas sciencebased tools help radiation protection professionals calculate radiation dose and risk riskthe probability of injury, disease or death from exposure to a hazard. Organ level internal dose assessmentexponential modeling version 1. Radiation dose to patients from radiopharmaceuticals. K03396 by the us food and drug administration as a software device. Tools for calculating radiation dose and risk epa bases its radiation protection activities on scientific assessment of health risks posed by radioactive substances. Estimation of radiation dose to patients from fdg whole.
In order to generate a dosimetry estimate, tissue residence times were generated, and associated tissue exposure and effective dose were calculated using the organ level internal dose assessmentexponential modelling olindaexm software. Comparison of internal dose estimates obtained using organlevel. The 5ht2a receptor agonist actions of 11ccimbi36 in vivo pharmacological effects in mice elicited by increasing doses of cimbi36 were assessed with the headtwitch response htr. Nioshtic2 publications search 20032215 internal dose. Values were calculated from human biodistribution data using olindaexm organ level internal dose assessmentexponential modeling software. The olindaexm personal computer code for calculating organ doses and effective doses in nuclear medicine studies was developed in 2004. I was wondering is there any free software similar to olindaexm 2. The personal computer code olindaexm, which is an acronym standing for organ level internal dose assessmentexponential modeling, was designed as. The radiation absorbed doses estimated for adult patients following intravenous injection of axumin are shown in table 1. Preclinical voxelbased dosimetry through gate monte carlo.
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